Serum globulin fractions in chronic rheumatic diseases; an electrophoretic study.

STUDY oi’ THE SERUM protein patterns in patients with chronic rheumatic diseases has already been reported in an earlier publication (1). In that work the proteins were separated by a salting-out technic and the fractions estimated by the biuret reaction. The results confirmed that hyperglobulinemia is a frequent finding in chronic rheumatic conditions, being often accompanied also, though in less degree, by hypoalbuminemia. The serum globulin was obtained in three fractions, and when hyperglobulinemia was noted the increments were located chiefly in the euglobulin and pseudoglobulin I fractions.